[CAS NO. 1005334-57-5] CVT-10216
PRODUCTS SPECIFICATIONS [1005334-57-5]
DESCRIPTION [1005334-57-5]
Overview
| MDL | MFCD18072197 |
|---|---|
| Molecular Weight | 465.48 |
| Molecular Formula | C24H19NO7S |
| SMILES | O=C(O)C1=CC=CC(COC2=CC=C3C(C(C4=CC=C(NS(=O)(C)=O)C=C4)=COC3=C2)=O)=C1 |
Summary
CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC 50 of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC 50 of 1.3 μM. CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects [1] .
IC50 & Target
IC50: 29 nM (ALDH-2) [1]
In Vivo
CVT-10216 (intraperitoneal injection; 3.75, 7.5, or 15 mg/kg) exhibits a increase in social interaction as a dose-dependent manner, punctuated by a 2-fold increase in social interaction after 15 mg/kg in Fawn-Hooded rats
[1]
.
CVT-10216 (intraperitoneal injection; 3.75 or 15 mg/kg) are determined 5 h into the third withdrawal.It has the anxiolytic effect of 15 mg/kg CVT-10216 in this model, but has no significant effects on locomotor activity
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMF : 25 mg/mL ( 53.71 mM ; Need ultrasonic and warming)
DMSO : 20 mg/mL ( 42.97 mM ; Need ultrasonic and warming)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1483 mL | 10.7416 mL | 21.4832 mL |
| 5 mM | 0.4297 mL | 2.1483 mL | 4.2966 mL |
| 10 mM | 0.2148 mL | 1.0742 mL | 2.1483 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.47 mM); Clear solution
