[CAS NO. 1017606-66-4] LPA2antagonist1
PRODUCTS SPECIFICATIONS [1017606-66-4]
DESCRIPTION [1017606-66-4]
Overview
| MDL | MFCD25976928 |
|---|---|
| Molecular Weight | 500.46 |
| Molecular Formula | C20H23Cl2N5O2S2 |
| SMILES | ClC1=C(Cl)C=C(S(=O)(N2CCN(C[C@@H](NC3=NC=NC4=C3SC=C4C)C)CC2)=O)C=C1 |
3 Publications Citing Use of MCE
Summary
LPA2 antagonist 1 is a LPA2 antagonist with an IC 50 of 17 nM.
IC50 & Target
IC50: 17 nM (LPA2) [1]
In Vitro
LPA2 antagonist 1 inhibits the phosphorylation of Erk induced by LPA in a concentration dependent manner. LPA2 antagonist 1 inhibits HCT-116 colon cancer cell proliferation caused by LPA in a doses dependent manner [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 199.82 mM )
DMF : ≥ 100 mg/mL ( 199.82 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9982 mL | 9.9908 mL | 19.9816 mL |
| 5 mM | 0.3996 mL | 1.9982 mL | 3.9963 mL |
| 10 mM | 0.1998 mL | 0.9991 mL | 1.9982 mL |
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1.
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.00 mM); Clear solution
