[CAS NO. 1143516-05-5] AEEA-AEEA
PRODUCTS SPECIFICATIONS [1143516-05-5]
DESCRIPTION [1143516-05-5]
Overview
| MDL | MFCD13184942 |
|---|---|
| Molecular Weight | 308.33 |
| Molecular Formula | C12H24N2O7 |
| SMILES | O=C(O)COCCOCCNC(COCCOCCN)=O |
Summary
AEEA-AEEA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . AEEA-AEEA is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs [1] [2] .
IC50 & Target
|
Cleavable |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker
[1]
.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
References
Synonyms
