[CAS NO. 120-21-8] 4-Diethylaminobenzaldehyde
PRODUCTS SPECIFICATIONS [120-21-8]
DESCRIPTION [120-21-8]
Overview
| MDL | MFCD00003382 |
|---|---|
| Molecular Weight | 177.24 |
| Molecular Formula | C11H15NO |
| SMILES | O=CC1=CC=C(N(CC)CC)C=C1 |
Summary
In Vitro
4-Diethylaminobenzaldehyde (DEAB) is reversible competitive inhibitor of ALDH1 (competitive with the aldehyde substrate) with a K
i
value of 4 nM, and irreversibly inactivates ALDH7A1 via formation of a stable, covalent acyl-enzyme species
[1]
.
The Temozolomide (TMZ)-resistant cell line LN18 is treated with a combination of TMZ and 4-Diethylaminobenzaldehyde for 10 days. As indicated by colony formation assay, the clonogenic capacity of LN18 cells exposed to TMZ in combination with 4-Diethylaminobenzaldehyde (DEAB) is significantly attenuated
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL ( 564.21 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.6421 mL | 28.2103 mL | 56.4207 mL |
| 5 mM | 1.1284 mL | 5.6421 mL | 11.2841 mL |
| 10 mM | 0.5642 mL | 2.8210 mL | 5.6421 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 3.25 mg/mL (18.34 mM); Clear solution
References
- [1] Luo M, et al. Diethylaminobenzaldehyde is a covalent, irreversible inactivator of ALDH7A1. ACS Chem Biol. 2015 Mar 20;10(3):693-7.
- [2] Araki N, et al. Screening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR-EcoScreen cells. Toxicol In Vitro. 2005 Sep;19(6):831-42.
Synonyms
