[CAS NO. 1264191-73-2] VTP-27999Hydrochloride
PRODUCTS SPECIFICATIONS [1264191-73-2]
DESCRIPTION [1264191-73-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 561.54 |
| Molecular Formula | C26H42Cl2N4O5 |
| SMILES | O=C(NC[C@H](C[C@@H]1COCCC1)NC)N(CCC2)C[C@]2([H])[C@](OCCNC(OC)=O)([H])C3=CC(Cl)=CC=C3.Cl |
Summary
VTP-27999 Hcl is an alkyl amine Renin inhibitor ; VTP-27999 is useful for Hypertension and End-Organ Diseases. IC50 value: Target: Renin
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01217736 | Vitae Pharmaceuticals, Inc.|Brigham and Women´s Hospital |
Renal Function
|
September 2010 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : ≥ 100 mg/mL ( 178.08 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.7808 mL | 8.9041 mL | 17.8082 mL |
| 5 mM | 0.3562 mL | 1.7808 mL | 3.5616 mL |
| 10 mM | 0.1781 mL | 0.8904 mL | 1.7808 mL |
References
- [1] Lanqi Jia et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751
- [2] New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082.
- [3] Ishchenko A, et al. Structure-based design technology contour and its application to the design of Renin inhibitors.J Chem Inf Model. 2012 Aug 27;52(8):2089-97. Epub 2012 Jul 25.
