[CAS NO. 1345853-49-7] Dynamin IN-2

Name: Dynamin IN-2
Brand: Arctom Scientific
SKU: HY-152216

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [1345853-49-7]

Store

Catalog

HY-152216

Brand

MCE

CAS

1345853-49-7

DESCRIPTION [1345853-49-7]

Overview

MDL	-
Molecular Weight	364.87
Molecular Formula	C22H21ClN2O
SMILES	ClC(C=C1)=CC=C1CNCC(CN2C3=CC=CC=C3C4=CC=CC=C42)O

For research use only. We do not sell to patients.

Summary

Dynamin IN-2 (compound 43), a Wiskostatin (HY-12534) analogue, is a potent dynamin inhibitor, with an IC ₅₀ of 1.0 μM for dynamin I GTPase . Dynamin IN-2 also blocks clathrin mediated endocytosis ( CME ), with an IC ₅₀ of 9.5 μM ^[1] .

IC50 & Target

IC ₅₀ : 1.0 ± 0.2 μM (dyn I GTPase), 9.5 ± 2.5 μM (CME) ^[1]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Cossar PJ, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001.