[CAS NO. 2230777-09-8] Taccalonolide AJ

Name: Taccalonolide AJ
Brand: Arctom Scientific
SKU: HY-N4208

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PRODUCTS SPECIFICATIONS [2230777-09-8]

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Catalog

HY-N4208

Brand

MCE

CAS

2230777-09-8

DESCRIPTION [2230777-09-8]

Overview

MDL	-
Molecular Weight	676.70
Molecular Formula	C34H44O14
SMILES	C[C@]1([C@@]2(O)C)[C@]3(OC2=O)[C@H]([C@@H](C)[C@@]4([H])[C@@]1([H])[C@@H]([C@]5([H])[C@@]4([C@H]([C@@H](OC(C)=O)[C@@]6([H])[C@@]5([H])[C@H](C([C@]7([H])[C@@]6([C@H]([C@@H](O8)[C@@H]8C7)OC(C)=O)C)=O)O)OC(C)=O)C)O)O3

For research use only. We do not sell to patients.

Summary

Taccalonolide AJ is a semi-synthesis compound with cellular microtubule stabilizing activity. Taccalonolide AJ exhibits high potency antiproliferative activity against cancer cells, with an IC ₅₀ of 4.2 nM for HeLa cells ^[1] .

IC50 & Target

microtubule ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 110 mg/mL ( 162.55 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4778 mL	7.3888 mL	14.7776 mL
5 mM	0.2956 mL	1.4778 mL	2.9555 mL
10 mM	0.1478 mL	0.7389 mL	1.4778 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Li J, et al. Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers. J Am Chem Soc. 2011 Nov 30;133(47):19064-7.