[CAS NO. 1350456-56-2] Fmoc-Val-Cit-PAB-MMAE

Name: Fmoc-Val-Cit-PAB-MMAE
Brand: Arctom Scientific
SKU: HY-19811

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PRODUCTS SPECIFICATIONS [1350456-56-2]

Store

Catalog

HY-19811

Brand

MCE

CAS

1350456-56-2

DESCRIPTION [1350456-56-2]

Overview

MDL	-
Molecular Weight	1345.67
Molecular Formula	C73H104N10O14
SMILES	O=C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@]([C@@H](C)CC)([H])[C@H](OC)CC(N(CCC2)[C@]2([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C3=CC=CC=C3)O)=O)=O)=O)=O)=O)C=C1)=O)=O)OCC4C5=CC=CC=C5C6=CC=CC=C46

For research use only. We do not sell to patients.

Summary

Fmoc-Val-Cit-PAB-MMAE consists the ADCs linker (Fmoc-Val-Cit-PAB) and potent tubulin inhibitor (MMAE). Fmoc-Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC.

IC50 & Target

Auristatin

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : ≥ 30 mg/mL ( 22.29 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7431 mL	3.7156 mL	7.4312 mL
5 mM	0.1486 mL	0.7431 mL	1.4862 mL
10 mM	0.0743 mL	0.3716 mL	0.7431 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 5.5 mg/mL (4.09 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 5.5 mg/mL (4.09 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 5.5 mg/mL (4.09 mM); Clear solution

* All of the co-solvents are available by MCE.