[CAS NO. 137076-54-1] DOTA-tri(t-butyl ester)

Name: DOTA-tri(t-butyl ester)
Brand: Arctom Scientific
SKU: HY-W034551

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PRODUCTS SPECIFICATIONS [137076-54-1]

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Catalog

HY-W034551

Brand

MCE

CAS

137076-54-1

DESCRIPTION [137076-54-1]

Overview

MDL	MFCD02259697
Molecular Weight	572.73
Molecular Formula	C28H52N4O8
SMILES	CC(C)(OC(CN1CCN(CC(O)=O)CCN(CC(OC(C)(C)C)=O)CCN(CC(OC(C)(C)C)=O)CC1)=O)C

For research use only. We do not sell to patients.

Summary

DOTA-tri(t-butyl ester) can be used in the synthesis of generations 3 (G3) nanoglobular magnetic resonance imaging (MRI) contrast agents for MR angiography and tumor angiogenesis imaging ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 87.30 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7460 mL	8.7301 mL	17.4602 mL
5 mM	0.3492 mL	1.7460 mL	3.4920 mL
10 mM	0.1746 mL	0.8730 mL	1.7460 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.37 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (4.37 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.37 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Kaneshiro TL, et, al. Synthesis and evaluation of globular Gd-DOTA-monoamide conjugates with precisely controlled nanosizes for magnetic resonance angiography. Biomacromolecules. 2008 Oct;9(10):2742-8.