[CAS NO. 1402612-56-9] KT172
PRODUCTS SPECIFICATIONS [1402612-56-9]
DESCRIPTION [1402612-56-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 452.55 |
| Molecular Formula | C28H28N4O2 |
| SMILES | O=C(N1N=NC(C2=CC=C(C3=C(OC)C=CC=C3)C=C2)=C1)N4CCCCC4CC5=CC=CC=C5 |
Summary
KT172 is a DAGLβ inhibitor with an IC 50 value of 11 nM. KT172 can be used for the research of metabolic and inflammatory [1] .
IC50 & Target
IC50: 11 nM (DAGLβ) [1]
In Vitro
KT172 (0-100 μM) has DAGLβ inhibition activity with an IC
50
value of 11 nM
[1]
.
KT172 (2 µM) blocks probe-labeling of DAGLβ and ABHD6 activities
[1]
.
KT172 (100 nM, 4 h) blocks DAGLβ activity in situ in the human prostate cancer cell line PC3 with high selectivity
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | Neuro2A cells |
| Concentration: | 25 nM |
| Incubation Time: | 4 h |
| Result: | DAGLβ activity and its inhibition by KT172 were detected only by HT-01 probe. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
