[CAS NO. 1411977-95-1] Acetylene-linker-Val-Cit-PABC-MMAE
PRODUCTS SPECIFICATIONS [1411977-95-1]
DESCRIPTION [1411977-95-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 1307.62 |
| Molecular Formula | C67H106N10O16 |
| SMILES | O=C([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(COCCOCCOCC#C)=O)=O)NC1=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N([C@H]([C@@H](CC(N2[C@H]([C@H](OC)[C@H](C(N[C@@H]([C@@H](O)C3=CC=CC=C3)C)=O)C)CCC2)=O)OC)[C@@H](C)CC)C)=O)=O)=O)C=C1 |
Summary
Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) consists the ADCs linker (Acetylene-linker-Val-Cit-PABC) and potent tubulin inhibitor (MMAE). Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) is a drug-linker conjugate for ADC.
IC50 & Target
|
Auristatin |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
DMSO : 50 mg/mL ( 38.24 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.7647 mL | 3.8237 mL | 7.6475 mL |
| 5 mM | 0.1529 mL | 0.7647 mL | 1.5295 mL |
| 10 mM | 0.0765 mL | 0.3824 mL | 0.7647 mL |
