[CAS NO. 1417162-36-7] RI-2
PRODUCTS SPECIFICATIONS [1417162-36-7]
DESCRIPTION [1417162-36-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 433.28 |
| Molecular Formula | C21H18Cl2N2O4 |
| SMILES | O=C(C(C1=CC=C(OC)C=C1)=C2N3CCOCC3)N(C4=CC=C(Cl)C(Cl)=C4)C2=O |
Summary
RI-2 is a reversible RAD51 inhibitor, with an IC 50 of 44.17 μM, and specifically inhibits homologous recombination repair in human cells.
IC50 & Target
IC50: 44.17 μM (RAD51) [1]
In Vitro
RI-2 (7a) is a reversible RAD51 inhibitor, with an IC 50 of 44.17 μM. RI-2 specifically inhibits homologous recombination repair in human cells. RI-2 (150 μM) induces a significant sensitization of cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 130 mg/mL ( 300.04 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3080 mL | 11.5399 mL | 23.0798 mL |
| 5 mM | 0.4616 mL | 2.3080 mL | 4.6160 mL |
| 10 mM | 0.2308 mL | 1.1540 mL | 2.3080 mL |
