[CAS NO. 1448895-09-7] ML314

Name: ML314
Brand: Arctom Scientific
SKU: HY-16639

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PRODUCTS SPECIFICATIONS [1448895-09-7]

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Catalog

HY-16639

Brand

MCE

CAS

1448895-09-7

DESCRIPTION [1448895-09-7]

Overview

MDL	-
Molecular Weight	420.50
Molecular Formula	C24H28N4O3
SMILES	COC1=CC=CC=C1N2CCN(C3=C4C=C(OC)C(OC)=CC4=NC(C5CC5)=N3)CC2

For research use only. We do not sell to patients.

Summary

ML314 is a potent molecule agonist of NTR1 (EC ₅₀ = 1.9 μM); showed good selectivity against NTR2 and GPR35 , but does not stimulate Ca ²⁺ mobilization.

IC50 & Target

NTR1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 118.91 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3781 mL	11.8906 mL	23.7812 mL
5 mM	0.4756 mL	2.3781 mL	4.7562 mL
10 mM	0.2378 mL	1.1891 mL	2.3781 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (5.95 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.95 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Hershberger P, et al. Small Molecule Agonists for the Neurotensin 1 Receptor (NTR1 Agonists). Probe Reports from the NIH Molecular Libraries Program