[CAS NO. 1464051-44-2] Mal-VC-PAB-DM1
PRODUCTS SPECIFICATIONS [1464051-44-2]
DESCRIPTION [1464051-44-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 1248.81 |
| Molecular Formula | C61H82ClN9O17 |
| SMILES | C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(OCC5=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN6C(C=CC6=O)=O)=O)=O)=O)C=C5)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1 |
Summary
Mal-VC-PAB-DM1 is a drug-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker Mal-VC-PAB [1] .
IC50 & Target
|
Maytansinoids |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 75 mg/mL ( 60.06 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.8008 mL | 4.0038 mL | 8.0076 mL |
| 5 mM | 0.1602 mL | 0.8008 mL | 1.6015 mL |
| 10 mM | 0.0801 mL | 0.4004 mL | 0.8008 mL |
