[CAS NO. 1491158-62-3] Fmoc-Lys(Pal-Glu-OtBu)-OH
PRODUCTS SPECIFICATIONS [1491158-62-3]
DESCRIPTION [1491158-62-3]
Overview
| MDL | MFCD27952849 |
|---|---|
| Molecular Weight | 792.06 |
| Molecular Formula | C46H69N3O8 |
| SMILES | CCCCCCCCCCCCCCCC(N[C@H](C(OC(C)(C)C)=O)CCC(NCCCC[C@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)C(O)=O)=O)=O |
Summary
Fmoc-Lys(Pal-Glu-OtBu)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Fmoc-Lys(Pal-Glu-OtBu)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs [1] [2] .
IC50 & Target
|
Cleavable |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker
[1]
.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References
