[CAS NO. 1493694-70-4] UNC2250
PRODUCTS SPECIFICATIONS [1493694-70-4]
DESCRIPTION [1493694-70-4]
Overview
| MDL | MFCD27992060 |
|---|---|
| Molecular Weight | 440.58 |
| Molecular Formula | C24H36N6O2 |
| SMILES | CCCCNC1=NC(N[C@@H]2CC[C@@H](O)CC2)=C(C3=CC=C(CN4CCOCC4)C=N3)C=N1 |
1 Publications Citing Use of MCE
Summary
UNC2250 is a potent and selective Mer inhibitor with an IC 50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.
IC50 & Target
IC50: 1.7 nM (Mer) [1]
In Vitro
UNC2250 (5-500 nM; 1 hour) inhibits Mer phosphorylation in 697 B-ALL cells with an IC
50
value of 9.8 nM
[1]
.
UNC2250 efficiently inhibits ligand-dependent phosphorylation of a chimeric protein consisting of the extracellular and transmembrane domains of the epidermal growth factor (EGF) receptor and the intracellular tyrosine kinase domain of Mer
[1]
.
UNC2250 incubation inhibits colony formation in soft agar cultures of the BT-12 rhabdoid tumor and the Colo699 NSCLC cell lines
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | 697 B-ALL cells |
| Concentration: | 5, 10, 20, 50, 100, 250, 500 nM |
| Incubation Time: | 1 hour |
| Result: | Inhibits Mer phosphorylation in 697 B-ALL cells with an IC 50 value of 9.8 nM. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 20 mg/mL ( 45.39 mM ; ultrasonic and warming and heat to 60°C)
0.1 M HCL : 12.5 mg/mL ( 28.37 mM ; ultrasonic and adjust pH to 3 with HCl)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2697 mL | 11.3487 mL | 22.6974 mL |
| 5 mM | 0.4539 mL | 2.2697 mL | 4.5395 mL |
| 10 mM | 0.2270 mL | 1.1349 mL | 2.2697 mL |
References
