[CAS NO. 1508286-18-7] SHMT-IN-1

Name: SHMT-IN-1
Brand: Arctom Scientific
SKU: HY-129651

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PRODUCTS SPECIFICATIONS [1508286-18-7]

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Catalog

HY-129651

Brand

MCE

CAS

1508286-18-7

MDL	-
Molecular Weight	375.25
Molecular Formula	C18H16Cl2N4O
SMILES	N#CC(C1(C2CCC2)C3=CC(Cl)=CC(Cl)=C3)=C(N)OC4=C1C(C)=NN4

For research use only. We do not sell to patients.

SHMT-IN-1 (compound (±)-46) is a potent inhibitor of plasmodial serine hydroxymethyltransferase (SHMT) . SHMT-IN-1 has antitumor activity ^[1] .

SHMT ^[1]

Solid

Room temperature in continental US; may vary elsewhere.

In Vitro:

DMSO : 250 mg/mL ( 666.22 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.54 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.54 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.54 mM); Clear solution

* All of the co-solvents are available by MCE.