[CAS NO. 152831-36-2] NE10790
PRODUCTS SPECIFICATIONS [152831-36-2]
DESCRIPTION [152831-36-2]
Overview
| MDL | MFCD20233001 |
|---|---|
| Molecular Weight | 247.14 |
| Molecular Formula | C8H10NO6P |
| SMILES | OC(C(O)=O)(P(O)(O)=O)CC1=CC=CN=C1 |
Summary
NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.
IC50 & Target
FPP synthase [1] .
In Vitro
NE 10790 inhibits incorporation of [ 14 C]mevalonic acid into Rab6, but not into H-Ras or Rap1, proteins that are modified by FTase and GGTase I, respectively. NE 10790 reduces viability in J774 cells. NE 10790 prevents prenylation of 22-26-kDa proteins that are not modified by FTase or GGTase I [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
0.1 M NaOH : 20 mg/mL ( 80.93 mM ; ultrasonic and adjust pH to 6 with NaOH)
H 2 O : 5 mg/mL ( 20.23 mM ; ultrasonic and adjust pH to 6 with NaOH)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.0463 mL | 20.2314 mL | 40.4629 mL |
| 5 mM | 0.8093 mL | 4.0463 mL | 8.0926 mL |
| 10 mM | 0.4046 mL | 2.0231 mL | 4.0463 mL |
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1.
Add each solvent one by one: PBS
Solubility: 2 mg/mL (8.09 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Synonyms
