[CAS NO. 159857-80-4] MC-Val-Cit-PAB

Name: MC-Val-Cit-PAB
Brand: Arctom Scientific
SKU: HY-78738

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PRODUCTS SPECIFICATIONS [159857-80-4]

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Catalog

HY-78738

Brand

MCE

CAS

159857-80-4

DESCRIPTION [159857-80-4]

Overview

MDL	MFCD26142966
Molecular Weight	572.65
Molecular Formula	C28H40N6O7
SMILES	CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(CO)C=C1)=O)=O)NC(CCCCCN2C(C=CC2=O)=O)=O

For research use only. We do not sell to patients.

Summary

MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate ^[1] .

IC50 & Target

Protease Cleavable

Cleavable

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 190 mg/mL ( 331.79 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7463 mL	8.7313 mL	17.4627 mL
5 mM	0.3493 mL	1.7463 mL	3.4925 mL
10 mM	0.1746 mL	0.8731 mL	1.7463 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 5.5 mg/mL (9.60 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 5.5 mg/mL (9.60 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 5.5 mg/mL (9.60 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders

Synonyms

L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N⁵-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-

N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N⁵-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide

6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino]-1-oxo-5-ureidopentan-2-yl)amino]-3-methyl-1-oxobutan-2-yl)hexanamide