[CAS NO. 159857-81-5] Mc-Val-Cit-PABC-PNP

Name: Mc-Val-Cit-PABC-PNP
Brand: Arctom Scientific
SKU: HY-20336

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PRODUCTS SPECIFICATIONS [159857-81-5]

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Catalog

HY-20336

Brand

MCE

CAS

159857-81-5

DESCRIPTION [159857-81-5]

Overview

MDL	MFCD22200431
Molecular Weight	737.76
Molecular Formula	C35H43N7O11
SMILES	CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1)=O)=O)NC(CCCCCN3C(C=CC3=O)=O)=O

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker . Mc-Val-Cit-PABC-PNP can be used in the synthesis of antibody-drug conjugates (ADCs) ^[1] .

IC50 & Target

Protease Cleavable

Cleavable

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 37 mg/mL ( 50.15 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3555 mL	6.7773 mL	13.5545 mL
5 mM	0.2711 mL	1.3555 mL	2.7109 mL
10 mM	0.1355 mL	0.6777 mL	1.3555 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 5 mg/mL (6.78 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 5 mg/mL (6.78 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Che-Leung Law et al. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders.Patent WO2005081711A2.

Synonyms

L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N⁵-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-

N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N⁵-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-L-ornithinamide

Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate

4-((S)-2-((S)-2-(6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl(4-nitrophenyl)carbonate

MC-Val-Cit-PAB-PNP