[CAS NO. 159858-22-7]  Fmoc-Val-Cit-PAB

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PRODUCTS SPECIFICATIONS [159858-22-7]

Store
Catalog
HY-19318
Brand
MCE
CAS
159858-22-7

DESCRIPTION [159858-22-7]

Overview

MDLMFCD22417106
Molecular Weight601.69
Molecular FormulaC33H39N5O6
SMILESCC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(CO)C=C1)=O)=O)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O

For research use only. We do not sell to patients.

Summary

Fmoc-Val-Cit-PAB is a cleavable linker for antibody-drug-conjugation (ADC).


IC50 & Target

Protease Cleavable

Cleavable


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL ( 138.49 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6620 mL 8.3099 mL 16.6199 mL
5 mM 0.3324 mL 1.6620 mL 3.3240 mL
10 mM 0.1662 mL 0.8310 mL 1.6620 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 6.25 mg/mL (10.39 mM); Suspended solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: 6.25 mg/mL (10.39 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: 6.25 mg/mL (10.39 mM); Suspended solution; Need ultrasonic

* All of the co-solvents are available by MCE.

Synonyms

L-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide