[CAS NO. 1642333-05-8] 22-(tert-Butoxy)-22-oxodocosanoic acid
PRODUCTS SPECIFICATIONS [1642333-05-8]
DESCRIPTION [1642333-05-8]
Overview
| MDL | MFCD30830215 |
|---|---|
| Molecular Weight | 426.67 |
| Molecular Formula | C26H50O4 |
| SMILES | O=C(OC(C)(C)C)CCCCCCCCCCCCCCCCCCCCC(O)=O |
Summary
22-(tert-Butoxy)-22-oxodocosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . 22-(tert-Butoxy)-22-oxodocosanoic acid is also a alkyl chain-based PROTAC linker that can be used in t
IC50 & Target
|
Non-cleavable |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker
[1]
.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References
