[CAS NO. 1670-14-0] Benzamidine hydrochloride
PRODUCTS SPECIFICATIONS [1670-14-0]
DESCRIPTION [1670-14-0]
Overview
| MDL | MFCD00013025 |
|---|---|
| Molecular Weight | 156.61 |
| Molecular Formula | C7H9ClN2 |
| SMILES | [H]Cl.N=C(C1=CC=CC=C1)N |
Summary
IC50 & Target
Ki: 97 µM (uPA), 21 µM (trypsin), 20 µM (tryptase), 110 µM (factor Xa) [1]
In Vitro
Benzamidine hydrochloride has weak inhibition for tPA and thrombin, with K
i
s of 750 µM and 320 µM, respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL ( 638.53 mM ; Need ultrasonic)
H 2 O : 50 mg/mL ( 319.26 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 6.3853 mL | 31.9264 mL | 63.8529 mL |
| 5 mM | 1.2771 mL | 6.3853 mL | 12.7706 mL |
| 10 mM | 0.6385 mL | 3.1926 mL | 6.3853 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 110 mg/mL (702.38 mM); Clear solution; Need ultrasonic
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (15.96 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (15.96 mM); Clear solution
References
- [1] Tanizawa K, et al. Proteolytic enzymes. VI. Aromatic amidines as competitive inhibitors of trypsin. J Biochem. 1971 May;69(5):893-9.
- [2] Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312.
Synonyms
