[CAS NO. 184161-19-1] L-Glutamine- 13 C 5
PRODUCTS SPECIFICATIONS [184161-19-1]
DESCRIPTION [184161-19-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 151.11 |
| Molecular Formula | 13C5H10N2O3 |
| SMILES | N[13C]([13CH2][13CH2][13C@H](N)[13C](O)=O)=O |
Summary
L-Glutamine-13C5 (L-Glutamic acid 5-amide-13C5) is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells [1] [2] .
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
H 2 O : 31.25 mg/mL ( 206.80 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 6.6177 mL | 33.0885 mL | 66.1770 mL |
| 5 mM | 1.3235 mL | 6.6177 mL | 13.2354 mL |
| 10 mM | 0.6618 mL | 3.3088 mL | 6.6177 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 16.67 mg/mL (110.32 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
References
- [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
- [2] Mary Corless , et al. Glutamine Regulates Expression of Key Transcription Factor, Signal Transduction, Metabolic Gene, and Protein Expression in a Clonal Pancreatic Beta-Cell Line. J Endocrinol. 2006 Sep;190(3):719-27.
- [3] Newsholme P, et al. Glutamine and glutamate as vital metabolites. Braz J Med Biol Res. 2003 Feb;36(2):153-63. Epub 2003 Jan 29.
