[CAS NO. 2055896-98-3] MC-Val-Cit-PAB-duocarmycinchloride
PRODUCTS SPECIFICATIONS [2055896-98-3]
DESCRIPTION [2055896-98-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 1055.05 |
| Molecular Formula | C54H65Cl2N9O9 |
| SMILES | ClC[C@H]1C2=C(C=C(O)C3=CC=CC=C23)N(C(C4=CC5=CC(OCC[N+](C)(C)CC6=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN7C(C=CC7=O)=O)=O)=O)=O)C=C6)=CC=C5N4)=O)C1.[Cl-] |
Summary
MC-Val-Cit-PAB-duocarmycin chloride is a drug-linker conjugate for ADC with potent antitumor activity by using Duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB.
IC50 & Target
|
Duocarmycins |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
DMSO : 130 mg/mL ( 123.22 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.9478 mL | 4.7391 mL | 9.4782 mL |
| 5 mM | 0.1896 mL | 0.9478 mL | 1.8956 mL |
| 10 mM | 0.0948 mL | 0.4739 mL | 0.9478 mL |
