[CAS NO. 2135640-93-4] (+)-JNJ-A07
PRODUCTS SPECIFICATIONS [2135640-93-4]
DESCRIPTION [2135640-93-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 578.96 |
| Molecular Formula | C28H26ClF3N2O6 |
| SMILES | OC(CCCOC1=CC(OC)=CC(NC(C2=CC=C(C=C2)Cl)C(N3C4=CC(OC(F)(F)F)=CC=C4CC3)=O)=C1)=O.[Rotation (+)] |
Summary
(+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. (+)-JNJ-A07 exerts nanomolar to picomolar activity against a panel of 21 clinical isolates. (+)-JNJ-A07 has a favourable pharmacokinetic profile that results in outstanding efficacy against dengue virus infection in mouse infection models [1] .
In Vitro
(+)-JNJ-A07 has a high barrier to resistance and prevents the formation of the viral replication complex by blocking the interaction between two viral proteins (NS3 and NS4B) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 172.72 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.7272 mL | 8.6362 mL | 17.2724 mL |
| 5 mM | 0.3454 mL | 1.7272 mL | 3.4545 mL |
| 10 mM | 0.1727 mL | 0.8636 mL | 1.7272 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (4.32 mM); Clear solution
