[CAS NO. 2150-43-8] Methyl 3,4-dihydroxybenzoate

Name: Methyl 3,4-dihydroxybenzoate
Brand: Arctom Scientific
SKU: HY-Z0548

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PRODUCTS SPECIFICATIONS [2150-43-8]

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Catalog

HY-Z0548

Brand

MCE

CAS

2150-43-8

DESCRIPTION [2150-43-8]

Overview

MDL	MFCD00016437
Molecular Weight	168.15
Molecular Formula	C8H8O4
SMILES	O=C(OC)C1=CC=C(O)C(O)=C1

For research use only. We do not sell to patients.

Summary

Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect ^[1] .

In Vitro

Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) alleviates the toxic effects of F ^- via modulating its bioavailability, intracellular calcium level, mitochondrial membrane integrity and redox signaling in A549 cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) (25 or 50 mg/kg bw/day) prevents the cellular F ^- accumulation and oxidative stress. Methyl 3,4-dihydroxybenzoate prevents the inflammatory and associated fibrosis progression by restoring the expression of RAGE and Nrf2 ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 297.35 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.9471 mL	29.7354 mL	59.4707 mL
5 mM	1.1894 mL	5.9471 mL	11.8941 mL
10 mM	0.5947 mL	2.9735 mL	5.9471 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (14.87 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (14.87 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (14.87 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Benzoic acid, 3,4-dihydroxy-, methyl ester

Protocatechuic acid, methyl ester

3,4-Dihydroxybenzoic acid methyl ester

Methyl protocatechuate

Methyl 3,4-dihydroxybenzoate

NSC 146458