[CAS NO. 2243689-80-5] DM21

Name: DM21
Brand: Arctom Scientific
SKU: HY-139441

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PRODUCTS SPECIFICATIONS [2243689-80-5]

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Catalog

HY-139441

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MCE

CAS

2243689-80-5

MDL	-
Molecular Weight	1215.84
Molecular Formula	C58H83ClN8O16S
SMILES	C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCCCCSCNC([C@H](C)NC([C@@H](C)NC([C@H](C)NC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)([H])O1

For research use only. We do not sell to patients.

DM21 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) ^[1] .

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Solid

Room temperature in continental US; may vary elsewhere.

In Vitro:

DMSO : 100 mg/mL ( 82.25 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 0.83 mg/mL (0.68 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 0.83 mg/mL (0.68 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 0.83 mg/mL (0.68 mM); Clear solution

* All of the co-solvents are available by MCE.