[CAS NO. 2394874-60-1] Axl/Mer/CSF1R-IN-1
PRODUCTS SPECIFICATIONS [2394874-60-1]
DESCRIPTION [2394874-60-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 531.48 |
| Molecular Formula | C25H24F3N5O5 |
| SMILES | O=C(C1=NN(CC)C(C)=C1OCC(F)(F)F)NC2=NC=C(C=C2)OC3=C4C=C(OC)C(OC)=CC4=NC=C3 |
Summary
Axl/Mer-IN-1 (Compound 1) is an Axl/Mer receptor tyrosine kinase ( Axl/Mer RTK ) and CSF1R inhibitor with K d s of <0.1 μM [1] .
IC50 & Target
Kd: <0.1 μM (Axl, Mer, CSF1R) [1]
In Vitro
Axl/Mer-IN-1 (Compound 1) inhibits cellular Axl activity with an IC 50 of <0.5 μM by H1299 Elisa assay. Axl/Mer-IN-1 inhibits cellular CSF1R activity with IC 50 s of <0.5 μM and <1.0 μM by THP-1 Elisa assay and by M-NFS-60 viability assay, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
