[CAS NO. 2414254-51-4] MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan

Name: MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan
Brand: Arctom Scientific
SKU: HY-148668

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PRODUCTS SPECIFICATIONS [2414254-51-4]

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Catalog

HY-148668

Brand

MCE

CAS

2414254-51-4

DESCRIPTION [2414254-51-4]

Overview

MDL	-
Molecular Weight	1074.12
Molecular Formula	C55H60FN9O13
SMILES	O=C(C=CC1=O)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCO[C@H](C3CC3)C(N[C@@H]4C5=C6C(C(N7C6)=CC([C@](O)(C(OC8)=O)CC)=C8C7=O)=NC9=CC(F)=C(C)C(CC4)=C95)=O)=O)=O)=O)=O)=O

For research use only. We do not sell to patients.

Summary

MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan is a drug-linker conjugates for ADC , consisting Exatecan (HY-13631). Exatecan is a DNA Topoisomerase I inhibitor (IC ₅₀ =2.2 μM) ^[1] .

IC50 & Target

Topoisomerase I

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Ying Hua, et al. Anti-B7H3 antibody-exatecan analog conjugate and medicinal use thereof: World Intellectual Property Organization, WO2020063673[P]. 2020-04-02.