[CAS NO. 24342-68-5] BnO-PEG6-OH
PRODUCTS SPECIFICATIONS [24342-68-5]
DESCRIPTION [24342-68-5]
Overview
| MDL | MFCD06797107 |
|---|---|
| Molecular Weight | 372.45 |
| Molecular Formula | C19H32O7 |
| SMILES | OCCOCCOCCOCCOCCOCCOCC1=CC=CC=C1 |
Summary
BnO-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . BnO-PEG6-OH is also a PEG-based PROTAC linker can be used in the synthesis of PROTACs [1] [2] .
IC50 & Target
|
Non-cleavable |
PEGs |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References
- [1] Shaoyun Xiang, et al. Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses there. Patent WO2016197946A1.
- [2] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
