[CAS NO. 24449-39-6] Tectol
PRODUCTS SPECIFICATIONS [24449-39-6]
DESCRIPTION [24449-39-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 450.53 |
| Molecular Formula | C30H26O4 |
| SMILES | OC1=C(C=CC=C2)C2=C(O3)C(C=CC3(C)C)=C1C4=C(C=CC5(C)C)C(O5)=C6C(C=CC=C6)=C4O |
Summary
Tectol, isolated from Lippia sidoides , exhibits significant activity against human leukemia cell lines HL60 and CEM [1] . Tectol is a farnesyltransferase (FTase) inhibitor with IC 50 s of 2.09 and 1.73 μM for human and T. brucei FTase, respectively. Tectol inhibits drug-resistant strain of P. falciparum (FcB1) with an IC 50 of 3.44 μM [1] [2] .
IC50 & Target
|
Plasmodium |
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
References
- [1] Costa SM, et al. Chemical constituents from Lippia sidoides and cytotoxic activity. J Nat Prod. 2001;64(6):792-795.
- [2] Cadelis MM, et al. Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors. Bioorg Med Chem. 2016;24(14):3102-3107.
