[CAS NO. 2446175-39-7] (R)-BAY-85-8501

Name: (R)-BAY-85-8501
Brand: Arctom Scientific
SKU: HY-19908B

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PRODUCTS SPECIFICATIONS [2446175-39-7]

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Catalog

HY-19908B

Brand

MCE

CAS

2446175-39-7

DESCRIPTION [2446175-39-7]

Overview

MDL	-
Molecular Weight	474.46
Molecular Formula	C22H17F3N4O3S
SMILES	N#CC1=C(C)N(C2=CC=CC(C(F)(F)F)=C2)C(N(C)[C@H]1C3=CC=C(C#N)C=C3S(=O)(C)=O)=O

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Chinese Academy of Sciences. 2019 Aug.

Summary

(R)-BAY-85-8501 is the less active Enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent inhibitor of Human Neutrophil Elastase (HNE) , with an IC ₅₀ of 65 pM ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 210.77 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1077 mL	10.5383 mL	21.0766 mL
5 mM	0.4215 mL	2.1077 mL	4.2153 mL
10 mM	0.2108 mL	1.0538 mL	2.1077 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73.