[CAS NO. 2498-50-2] 4-Aminobenzamidine dihydrochloride

Name: 4-Aminobenzamidine dihydrochloride
Brand: Arctom Scientific
SKU: HY-W018723

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PRODUCTS SPECIFICATIONS [2498-50-2]

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Catalog

HY-W018723

Brand

MCE

CAS

2498-50-2

DESCRIPTION [2498-50-2]

Overview

MDL	MFCD00013001
Molecular Weight	208.09
Molecular Formula	C7H11Cl2N3
SMILES	N=C(N)C1=CC=C(N)C=C1.[H]Cl.[H]Cl

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Bioorg Chem. November 2022, 106109.

Summary

4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor, also acting as a relatively weak urokinase type plasminogen activator (uPA) inhibitor (K _i =82 μM). 4-Aminobenzamidine can inhibit growth of a human prostate tumor in SCID mice ^[1] ^[2] .

IC50 & Target

Trypsin ^[1]
K _i : 82 μM (uPA) ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL ( 160.17 mM ; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8056 mL	24.0281 mL	48.0561 mL
5 mM	0.9611 mL	4.8056 mL	9.6112 mL
10 mM	0.4806 mL	2.4028 mL	4.8056 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1 mg/mL (4.81 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 1 mg/mL (4.81 mM); Clear solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1 mg/mL (4.81 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Benzenecarboximidamide, 4-amino-, hydrochloride (1:2)

Benzenecarboximidamide, 4-amino-, dihydrochloride

Benzamidine, p-amino-, dihydrochloride

p-Aminobenzamidine dihydrochloride

4-Aminobenzamidine dihydrochloride

4-Amidinoaniline dihydrochloride

SC 67235