[CAS NO. 2679821-44-2] Mal-PEG8-Phe-Lys-PAB-Exatecan

Name: Mal-PEG8-Phe-Lys-PAB-Exatecan
Brand: Arctom Scientific
SKU: HY-148380

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PRODUCTS SPECIFICATIONS [2679821-44-2]

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Catalog

HY-148380

Brand

MCE

CAS

2679821-44-2

DESCRIPTION [2679821-44-2]

Overview

MDL	-
Molecular Weight	1434.56
Molecular Formula	C73H92FN9O20
SMILES	O=C(C=CC1=O)N1CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCCN)C(NC(C=C3)=CC=C3COC(N[C@@H]4C5=C6C(C(N7C6)=CC([C@](O)(C(OC8)=O)CC)=C8C7=O)=NC9=CC(F)=C(C)C(CC4)=C95)=O)=O)=O)=O)=O

For research use only. We do not sell to patients.

Summary

Mal-PEG8-Phe-Lys-PAB-Exatecan (compound 15) is a drug-linker conjugate for ADC, composed of degradable linker Mal-PEG8-Phe-Lys-PAB and toxin molecule Exatecan (HY-13631) composition ^[1] .

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 180 mg/mL ( 125.47 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6971 mL	3.4854 mL	6.9708 mL
5 mM	0.1394 mL	0.6971 mL	1.3942 mL
10 mM	0.0697 mL	0.3485 mL	0.6971 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 4.5 mg/mL (3.14 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 4.5 mg/mL (3.14 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 4.5 mg/mL (3.14 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Manel KRAIEM. Treatment of cancer. Patent WO2021151984A1.