[CAS NO. 32981-85-4] Bz-RS-iSer(3-Ph)-OMe

Name: Bz-RS-iSer(3-Ph)-OMe
Brand: Arctom Scientific
SKU: HY-W009245

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PRODUCTS SPECIFICATIONS [32981-85-4]

Store

Catalog

HY-W009245

Brand

MCE

CAS

32981-85-4

DESCRIPTION [32981-85-4]

Overview

MDL	MFCD00673331
Molecular Weight	299.32
Molecular Formula	C17H17NO4
SMILES	O=C(OC)[C@H](O)[C@](NC(C1=CC=CC=C1)=O)([H])C2=CC=CC=C2

For research use only. We do not sell to patients.

Summary

Bz-RS-iSer(3-Ph)-OMe (compound 2), a Taxol derivative, inhibits HSV replication cycle at low cytotoxicity, blocks mitotic divisions of Vero cells, influences M-MSV induced tumor size and affects immune response by inhibiting PHA-induced T lymphocyte proliferation ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 417.61 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3409 mL	16.7045 mL	33.4091 mL
5 mM	0.6682 mL	3.3409 mL	6.6818 mL
10 mM	0.3341 mL	1.6705 mL	3.3409 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.17 mg/mL (7.25 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.17 mg/mL (7.25 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Krawczyk E, et al. Cytotoxic, antiviral (in-vitro and in-vivo), immunomodulatory activity and influence on mitotic divisions of three taxol derivatives: 10-deacetyl-baccatin III, methyl (N-benzoyl-(2'R,3'S)-3'-phenylisoserinate) and N-benzoyl-(2'R,3'S)-3'

Synonyms

Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, methyl ester, (αR,βS)-

Isoserine, N-benzoyl-3-phenyl-, methyl ester, (2R,3S)-

Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, methyl ester, [R-(R*,S*)]-

(2R,3S)-N-Benzoyl-3-phenylisoserine methyl ester

Methyl (2R,3S)-N-benzoylphenylisoserinate

Methyl (-)-(2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropionate

(2R,3S)-Methyl 3-benzoylamino-2-hydroxy-3-phenylpropanoate

LKT-T 0104