[CAS NO. 331242-61-6] N-Boc-PEG6-alcohol
PRODUCTS SPECIFICATIONS [331242-61-6]
DESCRIPTION [331242-61-6]
Overview
| MDL | MFCD28385472 |
|---|---|
| Molecular Weight | 381.46 |
| Molecular Formula | C17H35NO8 |
| SMILES | O=C(OC(C)(C)C)NCCOCCOCCOCCOCCOCCO |
Summary
N-Boc-PEG6-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs . N-Boc-PEG6-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1] .
IC50 & Target
|
Cleavable |
PEGs |
Alkyl/ether |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Viscous liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
