[CAS NO. 394237-61-7] M77976
PRODUCTS SPECIFICATIONS [394237-61-7]
DESCRIPTION [394237-61-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 296.32 |
| Molecular Formula | C17H16N2O3 |
| SMILES | COC1=CC=C(C=C1)C2=C(NN=C2C3=CC=C(C=C3O)O)C |
Summary
M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4) , with an IC 50 of 648 μM. M77976 is potential for the research of obesity and diabetes [1] .
IC50 & Target
IC50: 648 μM (PDK4) [1]
In Vitro
M77976 binds to the ATP-binding pocket of PDK4 and causes local conformational changes with complete disordering of the ATP lid
[1]
.
M77976 makes hydrophobic interactions with the side chains of Asn258, Ala262, Val298, Leu306 and Thr358 of PDK4
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 843.68 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3747 mL | 16.8736 mL | 33.7473 mL |
| 5 mM | 0.6749 mL | 3.3747 mL | 6.7495 mL |
| 10 mM | 0.3375 mL | 1.6874 mL | 3.3747 mL |
