[CAS NO. 400647-59-8] Doxorubicin-SMCC
PRODUCTS SPECIFICATIONS [400647-59-8]
DESCRIPTION [400647-59-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 762.76 |
| Molecular Formula | C39H42N2O14 |
| SMILES | C[C@@H]1O[C@H](C[C@@H]([C@@H]1O)NC(C2CCC(CC2)CN3C(C=CC3=O)=O)=O)O[C@H]4C[C@](O)(C(CO)=O)CC5=C(O)C(C(C6=C7C(OC)=CC=C6)=O)=C(C7=O)C(O)=C45 |
Summary
Doxorubicin-SMCC is a drug-linker conjugate for ADC . Doxorubicin-SMCC contains a non-cleavable ADC linker and a DNA topoisomerase II inhibitor Doxorubicin [1] .
IC50 & Target
|
Daunorubicins/Doxorubicins |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 62.5 mg/mL ( 81.94 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.3110 mL | 6.5551 mL | 13.1103 mL |
| 5 mM | 0.2622 mL | 1.3110 mL | 2.6221 mL |
| 10 mM | 0.1311 mL | 0.6555 mL | 1.3110 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: 2.08 mg/mL (2.73 mM); Suspended solution; Need ultrasonic
