[CAS NO. 477-49-6] Podophyllotoxone

Name: Podophyllotoxone
Brand: Arctom Scientific
SKU: HY-N2415

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PRODUCTS SPECIFICATIONS [477-49-6]

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Catalog

HY-N2415

Brand

MCE

CAS

477-49-6

DESCRIPTION [477-49-6]

Overview

MDL	-
Molecular Weight	412.39
Molecular Formula	C22H20O8
SMILES	O=C1[C@]([C@]2([H])CO1)([H])[C@@](C(C=C3OC)=CC(OC)=C3OC)([H])C4=CC(OCO5)=C5C=C4C2=O

For research use only. We do not sell to patients.

Summary

Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the tubulin polymerization ^[1] .

IC50 & Target

Microtubule/Tubulin ^[1]

In Vitro

Podophyllotoxone inhibits human prostate cancer cells PC3 and DU145 growth with IC ₅₀ values of 14.7 and 20.6 µM ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 242.49 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4249 mL	12.1244 mL	24.2489 mL
5 mM	0.4850 mL	2.4249 mL	4.8498 mL
10 mM	0.2425 mL	1.2124 mL	2.4249 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.06 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.06 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.06 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Juan Li , et al. Absolute Configuration of Podophyllotoxone and Its Inhibitory Activity Against Human Prostate Cancer Cells. Chin J Nat Med. 2015 Jan;13(1):59-64.

Synonyms

Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxole-5,8-dione, 5a,6,8a,9-tetrahydro-9-(3,4,5-trimethoxyphenyl)-, (5aR,8aR,9R)-

Podophyllotoxone

Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxole-5,8-dione, 5a,6,8a,9-tetrahydro-9-(3,4,5-trimethoxyphenyl)-, [5aR-(5aα,8aβ,9α)]-

(5aR,8aR,9R)-5a,6,8a,9-Tetrahydro-9-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxole-5,8-dione

Podophyllotoxinone