[CAS NO. 480998-12-7] MC-DOXHZNhydrochloride
PRODUCTS SPECIFICATIONS [480998-12-7]
DESCRIPTION [480998-12-7]
Overview
| MDL | MFCD25371995 |
|---|---|
| Molecular Weight | 787.21 |
| Molecular Formula | C37H43ClN4O13 |
| SMILES | [H][C@@]1(O[C@H]2C[C@@](/C(CO)=N\NC(CCCCCN3C(C=CC3=O)=O)=O)(O)CC(C2=C4O)=C(O)C5=C4C(C6=C(OC)C=CC=C6C5=O)=O)O[C@@H](C)[C@@H](O)[C@@H](N)C1.[H]Cl |
5 Publications Citing Use of MCE
Summary
MC-DOXHZN ((E/Z)-Aldoxorubicin) hydrochloride is an albumin-binding prodrug of Doxorubicin (DNA topoisomerase II inhibitor), with acid-sensitive properties [1] .
IC50 & Target
|
Topoisomerase II |
Daunorubicins/Doxorubicins |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 25 mg/mL ( 31.76 mM ; Need ultrasonic)
H 2 O : 12.5 mg/mL ( 15.88 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.2703 mL | 6.3515 mL | 12.7031 mL |
| 5 mM | 0.2541 mL | 1.2703 mL | 2.5406 mL |
| 10 mM | 0.1270 mL | 0.6352 mL | 1.2703 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (2.64 mM); Clear solution
