[CAS NO. 500-66-3] Olivetol
PRODUCTS SPECIFICATIONS [500-66-3]
DESCRIPTION [500-66-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 180.24 |
| Molecular Formula | C11H16O2 |
| SMILES | OC1=CC(CCCCC)=CC(O)=C1 |
Summary
Olivetol is a naturally phenol found in lichens and produced by certain insects, acting as a competitive inhibitor of the cannabinoid receptors CB1 and CB2 [3] . Olivetol also inhibits CYP2C19 and CYP2D6 activity, with IC 50 s of 15.3 μM, 7.21 μM and K i s of 2.71 μM, 2.87 μM, respectively [1] [2] .
IC50 & Target
|
CYP2 |
In Vitro
Olivetol inhibits the (S)-mephenytoin 4'-hydroxylase activity of CYP2C19 activity with an IC
50
of 15.3 μM and a K
i
of 2.71 μM
[1]
. Olivetol also inhibits AMMC O-demethylase activity of recombinant CYP2D6 with an IC
50
of 7.21 μM and a K
i
of 2.87 μM
[2]
.
Olivetol is a competitive inhibitor of the cannabinoid receptors CB1 and CB2
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Hypogymnia tubulosa
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL ( 554.82 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.5482 mL | 27.7408 mL | 55.4816 mL |
| 5 mM | 1.1096 mL | 5.5482 mL | 11.0963 mL |
| 10 mM | 0.5548 mL | 2.7741 mL | 5.5482 mL |
References
- [1] Jiang R, et al. Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Drug Metab Pharmacokinet. 2013;28(4):332-8.
- [2] Yamaori S, et al. Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Drug Metab Dispos. 2011 Nov;39(11):2049-56.
- [3] James J. Carberry , et al. Composition of Olivetol and Method of Use to Reduce or Inhibit the Effects of Tetrahydrocannabinol in the Human Body. US20170143644A1
Synonyms
