[CAS NO. 514-07-8] Taraxerone
PRODUCTS SPECIFICATIONS [514-07-8]
DESCRIPTION [514-07-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 424.70 |
| Molecular Formula | C30H48O |
| SMILES | CC1(C)C(CC[C@]2(C)[C@@]3([H])CC[C@@]4(C)[C@]5([H])CC(C)(C)CC[C@@](C)5CC=C4[C@@](C)3CC[C@@]12[H])=O |
Summary
Taraxerone is isolated from Sedum sarmentosum . Taraxerone enhances effects on alcohol dehydrogenase ( ADH ) and acetaldehyde dehydrogenase ( ALDH ) activities with EC 50 values of 512.42 and 500.16 μM, respectively [1] .
IC50 & Target
EC50: 512.42 μM (ADH); 500.16 μM (ALDH) [1]
In Vivo
Taraxerone significantly lowers the plasma alcohol and acetaldehyde concentrations in mice. Compare to the control group, the ADH and ALDH expressions in the liver tissues are abruptly increased in the taraxerone-treated groups after ethanol exposure
[1]
.
Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease induced by ethanol administration
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
THF : 10 mg/mL ( 23.55 mM ; Need ultrasonic)
DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3546 mL | 11.7730 mL | 23.5460 mL |
| 5 mM | 0.4709 mL | 2.3546 mL | 4.7092 mL |
| 10 mM | 0.2355 mL | 1.1773 mL | 2.3546 mL |
Synonyms
