[CAS NO. 53-03-2]  Prednisone

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PRODUCTS SPECIFICATIONS [53-03-2]

Store
Catalog
HY-B0214
Brand
MCE
CAS
53-03-2

DESCRIPTION [53-03-2]

Overview

MDL-
Molecular Weight358.43
Molecular FormulaC21H26O5
SMILESC[C@@]1(C2)[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3([H])C2=O)=O

For research use only. We do not sell to patients.


Summary

Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus [1] [2] .


In Vivo

Prednisone (intramuscular injection, 10 mg/kg once a day, on days 4 to 13) reduces the survival rate on days lower than the control group in BALB/c mice with encephalomyocarditis virus myocarditis. Besides, myocardial virus titers reaches a maximum on day 4, but there is no antibody titer, and on day 8 virus titers remains elevated and antibody titers is also high. On day 10, antibody titers are significantly lower than controls, while viral titers remains significantly elevated [2] .
Prednisone (5 mg/kg, intragastrically administration, daily) can cause changes in FA metabolism in SLE mouse (MRL/lpr) model [3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female MRL/lpr mice [3]
Dosage: 5 mg/kg
Administration: intragastrically administration, daily
Result: Elevated polyunsaturated FA, such as arachidonic acid and docosahexaenoic acid, and reduced the total level of n-6 polyunsaturated fatty acidsin.

Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT00736450 University of Nebraska|National Cancer Institute (NCI)|Genta Incorporated
Contiguous Stage II Adult Diffuse Large Cell Lymphoma|Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma|Stage I Adult Diffuse Large Cell Lymphoma|Stage III Adult Diffuse Large Cell Lymphoma|Stage IV Adult Diffuse Large Cell Lymphoma
July 2008 Not Applicable
NCT01940094 University of Pennsylvania|National Heart, Lung, and Blood Institute (NHLBI)|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)|Office of Rare Diseases (ORD)|National Center for Advancing Translational Sciences (NCATS)|Rare Diseases Clinical Research Network
Granulomatosis With Polyangiitis
February 2014 Phase 3
NCT02649413 Rabin Medical Center
Nephrotic Syndrome, Minimal Change
March 2016 Phase 4

Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 348.74 mM ; ultrasonic and warming and heat to 80°C)

H 2 O : 1 mg/mL ( 2.79 mM ; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7899 mL 13.9497 mL 27.8995 mL
5 mM 0.5580 mL 2.7899 mL 5.5799 mL
10 mM 0.2790 mL 1.3950 mL 2.7899 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.08 mg/mL (5.80 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.80 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.80 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
Ancortone
Bicortone
Colisone
Δ1-Cortisone
Dacortin
Decortancyl
Decortisyl
Δ1-Dehydrocortisone
1-Dehydrocortisone
Dekortin
Delta E
Delta-Cortelan
Deltacortisone
Deltacortone
Deltasone
Deltisone
Deltra
Di-Adreson
17α,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
Encortone
Enkorton
Hostacortin
Metacortandracin
Meticorten
Paracort
Prednisone
1,4-Pregnadiene-17α,21-diol-3,11,20-trione
Supercortil
Ultracorten
Ultracortene
Encorton
1,2-Dehydrocortisone
Dehydrocortisone
Δ-Cortisone
17,21-Dihydroxypregn-1,4-diene-3,11,20-trione
NSC 10023
Cortidelt
Prednison
Deltison
Rectodelt
Prednitone
Me-Korti
Prednicorm
Cartancyl
Uniplen
Prednicort
Liquid Pred
Pehacort
Adasone
Drazone
Apo-Prednisone
Winpred
Econosone
Fernisone
Delta-Dome
Nisona
Deltisona
Panafcort
Prednicot
Deltacortene
Dacorten
Prednidib
Sterapred
Cordrol
Prednicen M
Panasol
Predniment
Cortan
Dellacort
Dellacort A
Sone
Orasone
Delcortin
Decortin
Parmenison
Pulmison
Nurison
Retrocortine
Pronison
Prednilonga
17α,21-Dihydroxypregn-1,4-dien-3,11,20-trione
Prednidone