[CAS NO. 5536-17-4] Vidarabine

Name: Vidarabine
Brand: Arctom Scientific
SKU: HY-B0277

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PRODUCTS SPECIFICATIONS [5536-17-4]

Store

Catalog

HY-B0277

Brand

MCE

CAS

5536-17-4

DESCRIPTION [5536-17-4]

Overview

MDL	MFCD00065471
Molecular Weight	267.24
Molecular Formula	C10H13N5O4
SMILES	NC1=C(N=CN2[C@H]3[C@@H](O)[C@H](O)[C@@H](CO)O3)C2=NC=N1

For research use only. We do not sell to patients.

5 Publications Citing Use of MCE

Summary

Vidarabine (Ara-A) an antiviral agent which is active against herpes simplex and varicella zoster viruses ^[1] ^[2] . Vidarabine has IC ₅₀ s of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2 ^[2] . Vidarabine also has anti- orthopoxvirus activity ^[3] .

IC50 & Target

HSV-2

11.3 μg/mL (IC ₅₀ )

HSV-1

9.3 μg/mL (IC ₅₀ )

In Vitro

Vidarabine (Ara-A) is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the vaccinia VIRUS and varicella zoster virus ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00000985	National Institute of Allergy and Infectious Diseases (NIAID)	Herpes Simplex\|HIV Infections		Phase 3

Appearance

Solid

Source

Streptomyces

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 187.10 mM ; Need ultrasonic)

H ₂ O : 0.67 mg/mL ( 2.51 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7420 mL	18.7098 mL	37.4195 mL
5 mM	0.7484 mL	3.7420 mL	7.4839 mL
10 mM	0.3742 mL	1.8710 mL	3.7420 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (9.35 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (9.35 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (9.35 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

9H-Purin-6-amine, 9-β-D-arabinofuranosyl-

Adenine, 9-β-D-arabinofuranosyl-

9-β-D-Arabinofuranosyl-9H-purin-6-amine

Arabinosyladenine

9-β-D-Arabinofuranosyladenine

Adenine arabinoside

β-D-Arabinosyladenine

9-Arabinosyladenine

Vidarabine

Ara-A

CI-673

Vidarabin

Adenine β-D-arabinofuranoside

NSC 404241

Araadenosine

Spongoadenosine

9-β-D-Arabinoadenosine

6-Amino-9-β-D-arabinofuranosylpurine

9-β-D-Arabinosyladenine

Adenine 9-β-D-arabinofuranoside

β-D-Arabinofuranosyladenine

β-Ara-A

Vira-A

Arasena-A

Vidarabine anhydrous

NSC 247519

NQZ-071