[CAS NO. 646502-53-6] VcMMAE

Name: VcMMAE
Brand: Arctom Scientific
SKU: HY-15575

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [646502-53-6]

Store

Catalog

HY-15575

Brand

MCE

CAS

646502-53-6

DESCRIPTION [646502-53-6]

Overview

MDL	MFCD25372036
Molecular Weight	1316.63
Molecular Formula	C68H105N11O15
SMILES	CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N2[C@@]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C3=CC=CC=C3)=O)([H])CCC2)=O)C)=O)=O)=O)C=C1)=O)=O)NC(CCCCCN4C(C=CC4=O)=O)=O

For research use only. We do not sell to patients.

36 Publications Citing Use of MCE

Summary

VcMMAE (mc-vc-PAB-MMAE) is a drug-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).

IC50 & Target

Auristatin

In Vitro

Monomethyl auristatin E (MMAE) is efficiently released from SGN-35 within CD30 ⁺ cancer cells and, due to its membrane permeability, is able to exert cytotoxic activity on bystander cells ^[1] . MMAE sensitized colorectal and pancreatic cancer cells to IR in a schedule and dose dependent manner correlating with mitotic arrest. Radiosensitization is evidenced by decreased clonogenic survival and increased DNA double strand breaks in irradiated cells ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Monomethyl auristatin E (MMAE) in combination with IR results in tumor growth delay, tumor-targeted ACPP-cRGD-MMAE with IR produces a more robust and significantly prolonged tumor regression in xenograft models ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

* The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : ≥ 54 mg/mL ( 41.01 mM )

H ₂ O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7595 mL	3.7976 mL	7.5951 mL
5 mM	0.1519 mL	0.7595 mL	1.5190 mL
10 mM	0.0760 mL	0.3798 mL	0.7595 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

VcMMAE is dissolved in DMSO and then diluted with 0.9% NaCl ^[3] .