[CAS NO. 67319-28-2] m-PEG3-CH2CH2COOH
PRODUCTS SPECIFICATIONS [67319-28-2]
DESCRIPTION [67319-28-2]
Overview
| MDL | MFCD11041124 |
|---|---|
| Molecular Weight | 236.26 |
| Molecular Formula | C10H20O6 |
| SMILES | COCCOCCOCCOCCC(O)=O |
Summary
m-PEG3-CH2CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . m-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
IC50 & Target
|
Non-cleavable |
PEGs |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
