[CAS NO. 683239-16-9] 20-(tert-Butoxy)-20-oxoicosanoic acid
PRODUCTS SPECIFICATIONS [683239-16-9]
DESCRIPTION [683239-16-9]
Overview
| MDL | MFCD23136041 |
|---|---|
| Molecular Weight | 398.62 |
| Molecular Formula | C24H46O4 |
| SMILES | O=C(OC(C)(C)C)CCCCCCCCCCCCCCCCCCC(O)=O |
Summary
20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of
antibody-drug conjugates (ADCs)
. 20-(tert-Butoxy)-20-oxoicosanoic acid is also a alkyl chain-based
PROTAC
linker that can be used in the synthesis of
PROTACs
IC50 & Target
|
Non-cleavable |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker
[1]
.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References
