[CAS NO. 756526-04-2] NH2-PEG8-acid
PRODUCTS SPECIFICATIONS [756526-04-2]
DESCRIPTION [756526-04-2]
Overview
| MDL | MFCD11041146 |
|---|---|
| Molecular Weight | 441.51 |
| Molecular Formula | C19H39NO10 |
| SMILES | O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCN |
Summary
NH2-PEG9-acid is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1] . NH2-PEG9-acid also is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [2] .
IC50 & Target
|
Non-cleavable |
PEGs |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker [1] . PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL ( 113.25 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2650 mL | 11.3248 mL | 22.6495 mL |
| 5 mM | 0.4530 mL | 2.2650 mL | 4.5299 mL |
| 10 mM | 0.2265 mL | 1.1325 mL | 2.2650 mL |
References
Synonyms
