[CAS NO. 784105-33-5] Amino-PEG3-C2-acid
PRODUCTS SPECIFICATIONS [784105-33-5]
DESCRIPTION [784105-33-5]
Overview
| MDL | MFCD21607085 |
|---|---|
| Molecular Weight | 221.25 |
| Molecular Formula | C9H19NO5 |
| SMILES | O=C(O)CCOCCOCCOCCN |
Summary
Amino-PEG3-C2-acid is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Amino-PEG3-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1] .
IC50 & Target
|
Cleavable |
PEGs |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL ( 451.98 mM ; ultrasonic and warming and heat to 60°C)
DMF : 3.33 mg/mL ( 15.05 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.5198 mL | 22.5989 mL | 45.1977 mL |
| 5 mM | 0.9040 mL | 4.5198 mL | 9.0395 mL |
| 10 mM | 0.4520 mL | 2.2599 mL | 4.5198 mL |
